Endocrine Abstracts

Study question: Does the combination of estradiol valerate (EV) and dienogest (DNG) have favorable effects on inflammation and lipids compared with ethinyl estradiol (EE) + DNG?What is known already: Use of combined oral contraceptives (COCs) increases HDL-cholesterol and triglycerides and promotes low-grade inflammation. The metabolic effects of COCs depend on both estrogen and progestin components. To our knowledge this is the first study comparing COC...

Background: Combined oral contraceptives (COC) are known to have multiple beneficial effects besides contraception, but also cause some unwanted health outcomes. They interfere, for example, with metabolism, inflammation, hepatic protein synthesis and blood coagulation. COCs containing natural estrogens have recently been developed, yet little is known about their non-contraceptive effects compared to conventional COCs with ethinyl estradiol (EE). The aim of this study was to ...

ObjectiveTo study the predictive value of autoantibodies in progression to type 1 (T1DM) and type 2 (T2DM) diabetes after gestational diabetes (GDM) in a 23-year follow-up study. BackgroundWomen with GDM are at high risk for T2DM later in life, but also the risk of T1DM is increased. We have previously reported a prospective 6-year cohort study showing an association of islet cell and glutamic acid decarboxyl...

ObjectiveTo compare the effects of combined oral contraceptives (COCs) containing estradiol valerate (EV) and dienogest (DNG) with ethinyl estradiol (EE) and DNG on biomarkers of coagulation: thrombin generation (TG), prothrombin fragments F1+2 (F1+2) and D-dimer (D-Di). A DNG-only preparation was included as a control.BackgroundCOC use increases the risk of venous thromboembolism (VTE) 2-6-fold compa...